PKDCC

Across TCGA cell cohorts, PKDCC mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKDCC-associated genes across cancer lineages are C8orf74, TBC1D21, and PROP1. Each is linked with PKDCC in more than 1 cancer types. Because this analysis shows association rather than direction, both PKDCC-to-partner and partner-to-PKDCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf74 grouped by PKDCC-low versus PKDCC-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKDCC→partner) and Y-score (partner→PKDCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C8orf74 →	+0.029	+5.369	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PROP1 →	+0.028	+4.054	<.001	.004	3	1
LARGE_INTESTINE	TSGA10IP →	+0.104	+4.347	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C8orf74 by PKDCC expression — SOFT_TISSUE

Explore this box plot interactively →