PKDCC

Across TCGA cell cohorts, PKDCC mutation is significantly associated with the mutation status of many other genes, with 968 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKDCC-associated genes across cancer lineages are PODN, PLA2R1, and HYDIN. Each is linked with PKDCC in more than 2 cancer types. Because this analysis shows association rather than direction, both PKDCC-to-partner and partner-to-PKDCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PODN grouped by PKDCC-low versus PKDCC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKDCC→partner) and Y-score (partner→PKDCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PODN →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	PLA2R1 →	+2.894	+4.432	.005	.005	1	3
BLOOD_Leukemia	HYDIN →	+3.157	+4.665	.003	.003	1	3
BLOOD_Leukemia	LMTK2 →	+3.157	+4.665	.003	.003	1	3
BLOOD_Leukemia	ZNF831 →	+3.157	+4.665	.003	.003	1	3
BLOOD_Leukemia	CYP1B1 →	+3.672	+5.083	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 968 associations by consensus.

PODN by PKDCC expression — BLOOD_Leukemia

Explore this box plot interactively →