PKD2L2

Across TCGA cell cohorts, PKD2L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,361 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKD2L2-associated GO terms across cancer lineages are Post-transcriptional gene silencing, Regulation of protein K48-linked ubiquitination, and mRNA splice site recognition. Each is linked with PKD2L2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PKD2L2-to-partner and partner-to-PKD2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-transcriptional gene silencing grouped by PKD2L2-low versus PKD2L2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD2L2→partner) and Y-score (partner→PKD2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Post-transcriptional gene silencing →	+0.071	+0.129	<.001	<.001	3	9
SKIN	Regulation of protein K48-linked ubiquitination →	+0.107	+0.089	<.001	.004	3	9
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.179	+0.309	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of telomere maintenance →	+0.077	+0.279	<.001	.001	3	8
BLOOD_Lymphoma	Positive regulation of purine nucleotide biosynthetic process →	+0.062	+0.114	.006	.002	3	8
BLOOD_Lymphoma	Positive regulation of ATP biosynthetic process →	+0.063	+0.113	.005	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,361 associations by consensus.

Post-transcriptional gene silencing by PKD2L2 expression — BLOOD_Lymphoma

Explore this box plot interactively →