PKD2L2

Across TCGA pan-cancer cohorts, PKD2L2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PKD2L2 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PKD2L2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PKD2L2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

KIRC, UVM, and HNSC are the cancer types where PKD2L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.560	0.690	<.001	138	view →
UVM	DFS	Tertile	III,IV	0.226	0.856	.001	66	view →
HNSC	OS	Tertile	III,IV	0.615	0.233	.003	42	view →
SCLC	DFS	Tertile	All	0.164	0.625	.018	36	view →
UCS	OS	Median	IV	1.000	0.276	.018	30	view →
UCEC	DFS	Median	IV	0.906	0.500	.002	28	view →
BRCA	OS	Median	All	0.946	0.903	.004	27	view →
LUAD	OS	Median	III,IV	0.789	0.535	<.001	21	view →
LGG	DFS	Tertile	All	0.272	0.464	<.001	18	view →
MESO	OS	Tertile	All	0.429	0.687	.010	15	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
PCPG	DFS	Median	All	0.952	0.811	.003	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PKD2L2–KIRC (DFS)

Open the KIRC breakdown →