PKD2L2

Across TCGA cell cohorts, PKD2L2 mutation is significantly associated with the drug of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKD2L2-associated genes across cancer lineages are JNK Inhibitor VIII, GSK2801, and BDF00022089a. Each is linked with PKD2L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKD2L2-to-partner and partner-to-PKD2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK Inhibitor VIII grouped by PKD2L2-low versus PKD2L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD2L2→partner) and Y-score (partner→PKD2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JNK Inhibitor VIII →	+0.307	+2.807	.013	.035	3	1
LARGE_INTESTINE	GSK2801 →	+0.430	+2.900	.002	.015	3	1
LARGE_INTESTINE	BDF00022089a →	+0.320	+3.064	.022	.009	2	1
LARGE_INTESTINE	NU7441 →	+0.388	+3.000	.047	.021	1	1
LARGE_INTESTINE	741909 →	+0.883	+3.064	<.001	.009	1	1
LARGE_INTESTINE	743380 →	+0.816	+3.064	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK Inhibitor VIII by PKD2L2 expression — LARGE_INTESTINE

Explore this box plot interactively →