PKD2L1

Across TCGA patient cohorts, PKD2L1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD2L1-associated genes across cancer lineages are STAT3_pY705, 4E-BP1, and Cyclin-B1. Each is linked with PKD2L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PKD2L1-to-partner and partner-to-PKD2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PKD2L1-low versus PKD2L1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD2L1→partner) and Y-score (partner→PKD2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.231	-2.966	.049	.034	3	3
SKCM	4E-BP1 →	+0.277	+3.000	.035	.034	3	3
UCEC	Cyclin-B1 →	+0.474	+1.736	.015	.007	3	3
UCEC	eIF4E →	+0.160	+2.013	.029	.016	3	2
UCEC	MEK1 →	+0.345	+1.736	.006	.007	3	2
UCEC	ATM →	-0.505	-2.571	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

STAT3_pY705 by PKD2L1 expression — SKCM

Explore this box plot interactively →