PKD2L1

Across TCGA pan-cancer cohorts, PKD2L1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PKD2L1 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PKD2L1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PKD2L1 expression acts as an unfavorable survival marker, although some lineages such as CESC and KIRP show a favorable association.

CESC, ACC, and KIRP are the cancer types where PKD2L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.687	0.446	<.001	82	view →
ACC	DFS	Tertile	All	0.473	0.894	.003	68	view →
KIRP	OS	Median	All	0.788	0.603	<.001	59	view →
SKCM	OS	Quartile	II,III,IV	0.503	0.196	<.001	57	view →
LUSC	OS	Quartile	II,III,IV	0.666	0.866	<.001	40	view →
HNSC	DFS	Tertile	IV	0.506	0.262	.005	39	view →
KICH	OS	Tertile	II,III,IV	0.632	1.000	.004	26	view →
UVM	DFS	Median	All	0.388	0.735	.002	25	view →
STAD	DFS	Median	II,III,IV	0.478	0.231	.016	19	view →
LAML	DFS	Median	All	0.240	0.541	.011	18	view →
OV	OS	Quartile	III,IV	0.803	0.901	.003	16	view →
GBM	OS	Quartile	All	0.268	0.617	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PKD2L1–CESC (OS)

Open the CESC breakdown →