PKD2L1

Across TCGA cell cohorts, PKD2L1 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKD2L1-associated genes across cancer lineages are WFDC8, KRTAP12-3, and IFNW1. Each is linked with PKD2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKD2L1-to-partner and partner-to-PKD2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC8 grouped by PKD2L1-low versus PKD2L1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD2L1→partner) and Y-score (partner→PKD2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	WFDC8 →	+0.022	+4.867	<.001	.009	3	2
BLOOD_Myeloma	KRTAP12-3 →	+0.116	+4.807	<.001	.006	3	1
SOFT_TISSUE	IFNW1 →	+0.019	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2A25 →	+0.022	+4.930	<.001	.008	3	1
SOFT_TISSUE	RBMY1J →	+0.052	+4.930	<.001	.008	3	1
SOFT_TISSUE	DPEP2NB →	+0.021	+4.930	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

WFDC8 by PKD2L1 expression — BLOOD_Lymphoma

Explore this box plot interactively →