PKD1L2

Across TCGA patient cohorts, PKD1L2 mutation is significantly associated with the RNA expression of many other genes, with 7,014 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD1L2-associated genes across cancer lineages are NUP50, EIF2B2, and ZWINT. Each is linked with PKD1L2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PKD1L2-to-partner and partner-to-PKD1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP50 grouped by PKD1L2-low versus PKD1L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L2→partner) and Y-score (partner→PKD1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUP50 →	+0.463	+2.155	<.001	<.001	3	7
COAD	EIF2B2 →	+0.284	+2.710	.003	.003	3	6
UCEC	ZWINT →	+0.690	+1.854	<.001	<.001	3	6
UCEC	UBR7 →	+0.462	+1.638	<.001	<.001	3	6
LUAD	NDC80 →	+0.688	+1.596	.001	.006	3	6
SKCM	L2HGDH →	+0.479	+4.484	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,014 associations by consensus.

NUP50 by PKD1L2 expression — UCEC

Explore this box plot interactively →