PKD1L2

Across TCGA patient cohorts, PKD1L2 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD1L2-associated genes across cancer lineages are ASNS, RAD51, and c-Kit. Each is linked with PKD1L2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PKD1L2-to-partner and partner-to-PKD1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PKD1L2-low versus PKD1L2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L2→partner) and Y-score (partner→PKD1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.546	+2.321	.002	.006	3	5
COAD	RAD51 →	+0.151	+2.330	.009	.003	3	5
SKCM	c-Kit →	-0.533	-2.000	.005	.007	3	4
UCEC	Cyclin-B1 →	+0.529	+2.459	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.333	+1.736	<.001	<.001	3	3
STAD	Cyclin-E2 →	+0.137	+2.828	.025	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

ASNS by PKD1L2 expression — LUAD

Explore this box plot interactively →