PKD1L1

Across TCGA patient cohorts, PKD1L1 mutation is significantly associated with the RNA expression of many other genes, with 7,652 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD1L1-associated genes across cancer lineages are ZWINT, C4orf46, and PGAM1. Each is linked with PKD1L1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PKD1L1-to-partner and partner-to-PKD1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by PKD1L1-low versus PKD1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L1→partner) and Y-score (partner→PKD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.673	+1.807	<.001	<.001	3	6
UCEC	C4orf46 →	+0.564	+1.301	<.001	<.001	3	6
UCEC	PGAM1 →	+0.619	+1.333	<.001	<.001	3	6
LUAD	STIL →	+0.542	+1.949	<.001	.002	3	5
STAD	HJURP →	+0.756	+2.239	.001	.005	3	5
LUAD	DLGAP5 →	+0.687	+1.307	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,652 associations by consensus.

ZWINT by PKD1L1 expression — UCEC

Explore this box plot interactively →