PKD1L1

Across TCGA patient cohorts, PKD1L1 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD1L1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and S6_pS240_S244. Each is linked with PKD1L1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PKD1L1-to-partner and partner-to-PKD1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PKD1L1-low versus PKD1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L1→partner) and Y-score (partner→PKD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.651	+1.754	<.001	<.001	3	5
UCEC	Cyclin-B1 →	+0.645	+1.791	<.001	<.001	3	4
COAD	S6_pS240_S244 →	+0.273	+1.305	.033	.034	3	4
COAD	Cyclin-D1 →	+0.121	+2.330	.004	<.001	3	4
UCEC	FoxM1 →	+0.136	+1.037	.030	.006	3	4
UCEC	4E-BP1 →	+0.256	+2.523	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

Caspase-7-cleavedD198 by PKD1L1 expression — UCEC

Explore this box plot interactively →