PKD1L1

Across TCGA cell cohorts, PKD1L1 mutation is significantly associated with the RNA expression of many other genes, with 1,243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKD1L1-associated genes across cancer lineages are HBG1, MAGEB4, and EIF4ENIF1. Each is linked with PKD1L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PKD1L1-to-partner and partner-to-PKD1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBG1 grouped by PKD1L1-low versus PKD1L1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L1→partner) and Y-score (partner→PKD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HBG1 →	+0.050	+3.786	.002	.004	3	4
CNS	MAGEB4 →	+0.004	+2.058	<.001	.007	3	3
CNS	EIF4ENIF1 →	-0.379	-3.459	.006	.002	3	3
LUNG_NSCLC_LUAD	ZNF684 →	+0.431	+1.943	.003	.003	3	3
LUNG_NSCLC_LUAD	ING5 →	+0.511	+3.378	<.001	.002	3	3
LARGE_INTESTINE	DEPDC1 →	+0.651	+1.545	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,243 associations by consensus.

HBG1 by PKD1L1 expression — PANCREAS

Explore this box plot interactively →