PIWIL4

Across TCGA patient cohorts, PIWIL4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,750 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PIWIL4-associated proteins across cancer lineages are EPB41L2, KANK2, and PHLDB1_S430. Each is linked with PIWIL4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PIWIL4-to-partner and partner-to-PIWIL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIWIL4 versus EPB41L2 in HNSC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL4→partner) and Y-score (partner→PIWIL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EPB41L2 →	+0.405	+0.522	<.001	<.001	3	6
UCEC	KANK2 →	+0.506	+0.601	.001	.001	3	5
OV	PHLDB1_S430 →	+1.055	+0.541	<.001	<.001	3	4
BRCA	BCL6_S333 →	-0.478	-0.485	.002	.006	3	4
UCEC	CLIC2 →	+0.541	+0.539	<.001	.005	3	4
BRCA	CTIF →	+0.313	+0.496	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,750 associations by consensus.

PIWIL4 vs EPB41L2 — HNSC

Explore this scatter interactively →