PIWIL4

Across TCGA patient cohorts, PIWIL4 mutation is significantly associated with the RNA expression of many other genes, with 4,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIWIL4-associated genes across cancer lineages are RN7SKP245, CPLX3, and RN7SL248P. Each is linked with PIWIL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIWIL4-to-partner and partner-to-PIWIL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP245 grouped by PIWIL4-low versus PIWIL4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL4→partner) and Y-score (partner→PIWIL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SKP245 →	+0.130	+5.812	<.001	.003	3	2
CESC	CPLX3 →	+0.022	+6.342	<.001	.001	3	2
UCEC	RN7SL248P →	+0.039	+2.513	<.001	.004	3	2
UCEC	H2AC16 →	+0.406	+1.642	.002	<.001	3	2
LIHC	PNKDP1 →	+0.094	+3.019	.006	.009	3	2
LIHC	GSTM5P1 →	+0.099	+3.816	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,091 associations by consensus.

RN7SKP245 by PIWIL4 expression — CESC

Explore this box plot interactively →