Across TCGA patient cohorts, PIWIL2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIWIL2-associated genes across cancer lineages are PCNA, Caveolin-1, and p53. Each is linked with PIWIL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIWIL2-to-partner and partner-to-PIWIL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL2→partner) and Y-score (partner→PIWIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.246	+2.807	<.001	.002	3	3
SKCM	Caveolin-1 →	-0.558	-2.000	.021	.009	3	3
SKCM	p53 →	+0.171	+1.713	.019	.024	3	3
SKCM	CD49b →	+0.275	+1.874	.002	.049	3	3
UCEC	JNK_pT183_Y185 →	-0.163	-2.169	.002	.003	3	2
SKCM	p62 Lck ligand →	+0.392	+2.597	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

PIWIL2 survival (RNA) · tumor vs normal (RNA) · all PIWIL2 data types