Across TCGA cell cohorts, PIWIL2 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIWIL2-associated genes across cancer lineages are OR4X2, CBY1, and POLR3H. Each is linked with PIWIL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIWIL2-to-partner and partner-to-PIWIL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL2→partner) and Y-score (partner→PIWIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4X2 →	+0.031	+4.981	<.001	.008	3	1
LARGE_INTESTINE	CBY1 →	+0.575	+3.137	.004	.007	3	1
LARGE_INTESTINE	POLR3H →	+0.780	+3.212	.001	.006	3	1
LARGE_INTESTINE	RAD51C →	+0.964	+3.299	.001	.004	3	1
LARGE_INTESTINE	DDX25 →	+0.058	+3.254	.008	.007	3	1
LARGE_INTESTINE	PCCB →	+0.630	+3.125	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Exploration

PIWIL2 survival (RNA) · tumor vs normal (RNA) · all PIWIL2 data types