PIWIL1

Across TCGA patient cohorts, PIWIL1 mutation is significantly associated with the RNA expression of many other genes, with 5,464 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIWIL1-associated genes across cancer lineages are AGBL5, FAM162B, and DNAH14. Each is linked with PIWIL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIWIL1-to-partner and partner-to-PIWIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGBL5 grouped by PIWIL1-low versus PIWIL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL1→partner) and Y-score (partner→PIWIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AGBL5 →	+0.321	+1.722	.004	<.001	3	4
LUAD	FAM162B →	-0.705	-3.087	.001	<.001	3	4
LUAD	DNAH14 →	+0.396	+2.620	.001	.005	3	3
UCEC	SENP3-EIF4A1 →	+0.088	+2.237	<.001	<.001	3	3
UCEC	ZNF79 →	+0.370	+1.917	<.001	<.001	3	3
UCEC	XRCC6 →	+0.577	+1.938	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,464 associations by consensus.

AGBL5 by PIWIL1 expression — UCEC

Explore this box plot interactively →