PITX2

Across TCGA patient cohorts, PITX2 protein abundance is significantly associated with the RNA expression of many other genes, with 879 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PITX2-associated genes across cancer lineages are PACSIN2, NEFH, and TNRC6B. Each is linked with PITX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX2-to-partner and partner-to-PITX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PITX2 versus PACSIN2 in LUAD, with a Pearson correlation of -0.84.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX2→partner) and Y-score (partner→PITX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PACSIN2 →	-0.710	-3.994	.008	<.001	3	1
LUAD	NEFH →	-0.347	-3.994	.002	<.001	3	1
LUAD	TNRC6B →	-0.557	-3.995	.007	<.001	3	1
LUAD	RBX1 →	-0.400	-3.995	.002	<.001	3	1
LUAD	SNTA1 →	+1.382	+3.994	<.001	<.001	3	1
LUAD	CPQ →	-0.650	-3.995	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 879 associations by consensus.

PITX2 vs PACSIN2 — LUAD

Explore this scatter interactively →