PITX2

Across TCGA pan-cancer cohorts, PITX2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PITX2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PITX2 RNA is repressed in tumor relative to normal tissue. In most cancer types PITX2 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, LUAD, and BLCA are the cancer types where PITX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PITX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−0.531	<.001	11	view →
LUAD	Female	All	+1.235	<.001	9	view →
BLCA	Male	IV	−3.560	<.001	8	view →
KIRC	All	IV	+1.140	<.001	8	view →
READ	Female	All	+2.590	<.001	7	view →
LUSC	Female	All	+2.079	<.001	6	view →
UCEC	All	All	+0.847	.002	6	view →
COAD	All	II,III,IV	+0.822	.012	4	view →
PAAD	Female	All	+1.035	.008	2	view →
PRAD	All	All	−0.548	<.001	2	view →
LIHC	All	All	+0.220	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PITX2–KICH

Open the KICH breakdown →