PITX2

Across TCGA patient cohorts, PITX2 mutation is significantly associated with the RNA expression of many other genes, with 856 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITX2-associated genes across cancer lineages are OR4X2, RN7SL557P, and MTND2P38. Each is linked with PITX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PITX2-to-partner and partner-to-PITX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by PITX2-low versus PITX2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX2→partner) and Y-score (partner→PITX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR4X2 →	+0.026	+4.438	<.001	.006	3	3
LUSC	RN7SL557P →	+0.087	+4.733	.003	.004	3	3
COAD	MTND2P38 →	+0.190	+5.145	<.001	.007	3	2
CESC	HNRNPMP2 →	+0.075	+5.342	<.001	.002	3	2
COAD	NDUFA4P2 →	+0.672	+5.435	<.001	.005	3	2
COAD	HAUS1P3 →	+0.248	+6.003	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 856 associations by consensus.

OR4X2 by PITX2 expression — LUSC

Explore this box plot interactively →