PITX2

Across TCGA patient cohorts, PITX2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITX2-associated genes across cancer lineages are HSP70, Rictor_pT1135, and 4E-BP1. Each is linked with PITX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX2-to-partner and partner-to-PITX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by PITX2-low versus PITX2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX2→partner) and Y-score (partner→PITX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HSP70 →	-0.577	-3.169	.044	.019	3	2
UCEC	Rictor_pT1135 →	-0.074	-1.807	.040	.025	3	2
UCEC	4E-BP1 →	+0.286	+3.169	.002	.018	3	2
SKCM	Bap1-c-4 →	+0.398	+3.169	.015	.019	3	1
SKCM	B-Raf →	+0.563	+3.169	.004	.019	3	1
SKCM	eEF2K →	+0.468	+3.186	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

HSP70 by PITX2 expression — SKCM

Explore this box plot interactively →