PITX2

Across TCGA cell cohorts, PITX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,806 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PITX2-associated GO terms across cancer lineages are Cardiac neural crest cell migration involved in outflow tract morphogenesis, Adenohypophysis development, and Cardiac neural crest cell differentiation involved in heart development. Each is linked with PITX2 in more than 15 cancer types. Because this analysis shows association rather than direction, both PITX2-to-partner and partner-to-PITX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cardiac neural crest cell migration involved in outflow tract morphogenesis grouped by PITX2-low versus PITX2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX2→partner) and Y-score (partner→PITX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cardiac neural crest cell migration involved in outflow tract morphogenesis →	-0.334	-1.814	<.001	<.001	3	16
KIDNEY	Adenohypophysis development →	+1.870	+2.635	<.001	<.001	3	14
SOFT_TISSUE	Cardiac neural crest cell differentiation involved in heart development →	-0.261	-2.101	.002	.003	3	12
SOFT_TISSUE	Cardiac neural crest cell development involved in heart development →	-0.261	-2.101	.002	.003	3	12
SOFT_TISSUE	Cardiac neural crest cell development involved in outflow tract morphogenesis →	-0.261	-2.101	.002	.003	3	12
SOFT_TISSUE	Deltoid tuberosity development →	+1.199	+2.109	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,806 associations by consensus.

Cardiac neural crest cell migration involved in outflow tract morphogenesis by PITX2 expression — LUNG_SCLC

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