PITX2

Across TCGA cell cohorts, PITX2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PITX2-associated genes across cancer lineages are MAGEB4, TRDN, and LRRC3C. Each is linked with PITX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX2-to-partner and partner-to-PITX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PITX2-low versus PITX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX2→partner) and Y-score (partner→PITX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.019	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	TRDN →	+0.046	+4.054	<.001	.004	3	1
LARGE_INTESTINE	LRRC3C →	+0.344	+3.777	<.001	.007	3	1
BLOOD_Leukemia	OXGR1 →	+0.148	+3.847	<.001	.007	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB4 by PITX2 expression — LARGE_INTESTINE

Explore this box plot interactively →