PITPNM3

Across TCGA pan-cancer cohorts, PITPNM3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PITPNM3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PITPNM3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PITPNM3 is over-expressed in tumor, although a few such as LUAD and OV show the opposite, repressed pattern.

LUAD, OV, and HNSC are the cancer types where PITPNM3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PITPNM3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.305	<.001	4	view →
OV	All	All	−0.490	.038	2	view →
HNSC	All	II,III,IV	−0.216	.035	2	view →
LSCC	All	All	−0.146	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PITPNM3–LUAD

Open the LUAD breakdown →