PITPNM3

Across TCGA pan-cancer cohorts, PITPNM3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PITPNM3 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PITPNM3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PITPNM3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LIHC show a favorable association.

HNSC, PAAD, and LIHC are the cancer types where PITPNM3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.438	0.277	<.001	145	view →
PAAD	DFS	Tertile	All	0.156	0.380	.002	44	view →
LIHC	DFS	Tertile	III,IV	0.545	0.135	<.001	34	view →
ESCA	OS	Tertile	All	0.776	0.573	.006	30	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
UCEC	DFS	Median	IV	0.900	0.457	.001	24	view →
KIRP	DFS	Quartile	All	0.969	0.853	.006	21	view →
COAD	OS	Median	III,IV	0.868	0.678	.006	19	view →
ACC	DFS	Tertile	All	0.227	0.637	.003	16	view →
BRCA	DFS	Tertile	II,III,IV	0.524	0.640	.001	14	view →
SKCM	OS	Median	III,IV	0.274	0.572	.006	12	view →
PCPG	DFS	Quartile	All	0.757	0.934	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PITPNM3–HNSC (OS)

Open the HNSC breakdown →