PITPNM3

Across TCGA patient cohorts, PITPNM3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITPNM3-associated genes across cancer lineages are PCNA, ATM, and Caspase-7-cleavedD198. Each is linked with PITPNM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PITPNM3-to-partner and partner-to-PITPNM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PITPNM3-low versus PITPNM3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNM3→partner) and Y-score (partner→PITPNM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.222	+2.593	.032	.006	3	4
UCEC	ATM →	-0.598	-2.392	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.536	+1.926	.010	.008	3	4
STAD	Cyclin-E2 →	+0.202	+3.021	<.001	.017	3	3
UCEC	PDCD4 →	-0.456	-1.362	.006	.037	3	3
UCEC	cIAP →	+0.106	+1.389	.029	.023	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PCNA by PITPNM3 expression — COAD

Explore this box plot interactively →