PITPNM2

Across TCGA cell cohorts, PITPNM2 mutation is significantly associated with the RNA expression of many other genes, with 1,227 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PITPNM2-associated genes across cancer lineages are COQ5, KSR2, and TRAPPC3. Each is linked with PITPNM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PITPNM2-to-partner and partner-to-PITPNM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ5 grouped by PITPNM2-low versus PITPNM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNM2→partner) and Y-score (partner→PITPNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COQ5 →	+0.426	+3.169	.006	.006	3	3
BLOOD_Leukemia	KSR2 →	+0.256	+3.125	.001	<.001	3	3
BLOOD_Leukemia	TRAPPC3 →	+0.322	+3.115	.003	.009	3	3
BLOOD_Lymphoma	FAM183A →	+0.286	+3.523	<.001	.009	3	2
BLOOD_Lymphoma	OR13C3 →	+0.046	+4.169	<.001	.002	3	2
BLOOD_Lymphoma	PAGE3 →	+0.065	+4.058	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,227 associations by consensus.

COQ5 by PITPNM2 expression — LARGE_INTESTINE

Explore this box plot interactively →