PITPNM1

Across TCGA cell cohorts, PITPNM1 mutation is significantly associated with the RNA expression of many other genes, with 547 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PITPNM1-associated genes across cancer lineages are LMNB1, PCCB, and CLPP. Each is linked with PITPNM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITPNM1-to-partner and partner-to-PITPNM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMNB1 grouped by PITPNM1-low versus PITPNM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNM1→partner) and Y-score (partner→PITPNM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMNB1 →	+0.626	+2.451	.005	.009	3	2
LARGE_INTESTINE	PCCB →	+0.588	+2.447	.001	.006	3	2
LARGE_INTESTINE	CLPP →	+0.478	+3.588	.002	<.001	3	2
LARGE_INTESTINE	GID4 →	+0.562	+2.451	.001	.009	3	2
LARGE_INTESTINE	FEM1A →	+0.637	+3.502	<.001	.001	3	2
LARGE_INTESTINE	FBXO25 →	+0.818	+3.169	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 547 associations by consensus.

LMNB1 by PITPNM1 expression — LARGE_INTESTINE

Explore this box plot interactively →