PITPNB

Across TCGA pan-cancer cohorts, PITPNB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PITPNB data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PITPNB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PITPNB expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where PITPNB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.824	0.684	.006	20	view →
LUAD	OS	Median	II,III,IV	0.429	1.000	.004	19	view →
LSCC	OS	Tertile	All	1.000	0.910	.012	13	view →
UCEC	DFS	Median	All	0.928	0.791	.030	8	view →
CCRCC	DFS	Quartile	III,IV	0.791	0.343	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PITPNB–PDAC (DFS)

Open the PDAC breakdown →