PITPNB

Across TCGA pan-cancer cohorts, PITPNB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PITPNB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PITPNB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PITPNB is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where PITPNB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PITPNB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.941	<.001	12	view →
COAD	Female	II,III,IV	+0.835	<.001	11	view →
KIRC	Female	All	+0.594	<.001	10	view →
BLCA	All	IV	−1.120	.015	8	view →
LUSC	Male	II,III,IV	+0.932	<.001	6	view →
CHOL	Male	All	+1.278	<.001	4	view →
READ	All	III,IV	+1.054	<.001	4	view →
LIHC	Male	All	+0.406	.006	4	view →
THCA	Female	All	−0.334	<.001	4	view →
LUAD	All	All	+0.192	.021	3	view →
KIRP	All	IV	+0.627	.023	2	view →
ESCA	All	All	+0.628	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PITPNB–HNSC

Open the HNSC breakdown →