PITPNB

Across TCGA patient cohorts, PITPNB mutation is significantly associated with the RNA expression of many other genes, with 2,601 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITPNB-associated genes across cancer lineages are RNU6-1103P, OR4F4, and ATF1P1. Each is linked with PITPNB in more than 1 cancer types. Because this analysis shows association rather than direction, both PITPNB-to-partner and partner-to-PITPNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1103P grouped by PITPNB-low versus PITPNB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNB→partner) and Y-score (partner→PITPNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1103P →	+0.269	+9.057	<.001	.003	3	2
SKCM	OR4F4 →	+0.038	+5.797	<.001	.001	3	2
SKCM	ATF1P1 →	+0.070	+4.513	<.001	.009	3	2
UCEC	RNA5SP419 →	+0.575	+2.299	<.001	.001	3	2
BRCA	MIR6515 →	+0.717	+8.055	<.001	.007	3	1
SKCM	CYMP-AS1 →	+0.015	+4.513	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,601 associations by consensus.

RNU6-1103P by PITPNB expression — BRCA

Explore this box plot interactively →