PITPNB

Across TCGA patient cohorts, PITPNB mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITPNB-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with PITPNB in more than 1 cancer types. Because this analysis shows association rather than direction, both PITPNB-to-partner and partner-to-PITPNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PITPNB-low versus PITPNB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNB→partner) and Y-score (partner→PITPNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.308	+2.115	.048	.019	3	1
UCEC	EGFR_pY1068 →	-0.239	-2.321	.029	.034	3	1
UCEC	eIF4E →	+0.234	+3.321	.010	.010	2	2
UCEC	JNK2 →	+0.263	+2.115	.002	.019	3	1
UCEC	MEK1 →	+0.460	+2.115	.003	.019	3	1
UCEC	mTOR_pS2448 →	-0.146	-2.115	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eEF2 by PITPNB expression — UCEC

Explore this box plot interactively →