PITPNB

Across TCGA cell cohorts, PITPNB mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PITPNB-associated genes across cancer lineages are RTP2, WFDC5, and MRGPRG. Each is linked with PITPNB in more than 1 cancer types. Because this analysis shows association rather than direction, both PITPNB-to-partner and partner-to-PITPNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTP2 grouped by PITPNB-low versus PITPNB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNB→partner) and Y-score (partner→PITPNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RTP2 →	+0.021	+4.539	<.001	.007	3	1
LUNG_NSCLC_LUAD	WFDC5 →	+0.146	+4.095	.001	.009	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.025	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	GYPB →	+0.082	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RTP2 by PITPNB expression — BLOOD_Leukemia

Explore this box plot interactively →