PITPNA

Across TCGA patient cohorts, PITPNA mutation is significantly associated with the RNA expression of many other genes, with 612 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITPNA-associated genes across cancer lineages are RNU6-1122P, RNU6-968P, and RBPMS2P1. Each is linked with PITPNA in more than 1 cancer types. Because this analysis shows association rather than direction, both PITPNA-to-partner and partner-to-PITPNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1122P grouped by PITPNA-low versus PITPNA-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNA→partner) and Y-score (partner→PITPNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1122P →	+0.437	+5.792	<.001	.003	3	2
COAD	RNU6-968P →	+0.412	+5.283	<.001	.006	3	1
COAD	RBPMS2P1 →	+0.100	+6.547	.001	.001	3	1
COAD	RNU7-143P →	+0.642	+5.693	<.001	.003	3	1
COAD	TRIM53CP →	+0.047	+6.547	.004	.001	3	1
COAD	GLTPP1 →	+0.098	+5.790	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 612 associations by consensus.

RNU6-1122P by PITPNA expression — LUSC

Explore this box plot interactively →