PITPNA-AS1

Across TCGA pan-cancer cohorts, PITPNA-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PITPNA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PITPNA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PITPNA-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where PITPNA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PITPNA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.862	<.001	10	view →
THCA	Male	All	−0.525	<.001	9	view →
LIHC	Male	II,III,IV	+1.224	<.001	8	view →
LUAD	Male	All	+0.733	<.001	8	view →
LUSC	Female	All	+1.214	<.001	6	view →
BRCA	Female	II,III,IV	−0.437	<.001	6	view →
BLCA	Female	III,IV	+0.742	.023	4	view →
CHOL	Male	All	+2.106	<.001	3	view →
KIRP	Female	II,III,IV	+1.136	.009	3	view →
HNSC	Male	III,IV	+0.640	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PITPNA-AS1–KICH

Open the KICH breakdown →