PIR

Across TCGA patient cohorts, PIR protein abundance is significantly associated with the RNA expression of many other genes, with 15,391 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIR-associated genes across cancer lineages are FUNDC1, PRDX1, and TIMM17B. Each is linked with PIR in more than 6 cancer types. Because this analysis shows association rather than direction, both PIR-to-partner and partner-to-PIR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIR versus FUNDC1 in HNSC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIR→partner) and Y-score (partner→PIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FUNDC1 →	+0.716	+0.579	.003	.002	3	7
HNSC	PRDX1 →	+1.111	+0.760	<.001	<.001	3	6
UCEC	TIMM17B →	+0.706	+0.593	.003	.002	3	6
HNSC	RPL39L →	+1.169	+0.642	<.001	<.001	3	6
LSCC	NQO1 →	+1.972	+0.808	<.001	<.001	3	6
LSCC	NMRAL2P →	+3.501	+1.019	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,391 associations by consensus.

PIR vs FUNDC1 — HNSC

Explore this scatter interactively →