PIR

Across TCGA pan-cancer cohorts, PIR RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PIR data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PIR RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIR expression acts as an unfavorable survival marker, although some lineages such as OV and LUSC show a favorable association.

KIRP, KICH, and OV are the cancer types where PIR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.849	0.962	<.001	84	view →
KICH	DFS	Median	II,III,IV	0.535	0.958	<.001	71	view →
OV	DFS	Median	III,IV	0.419	0.322	.001	66	view →
LUAD	OS	Median	III,IV	0.506	0.784	.003	53	view →
LUSC	DFS	Tertile	All	0.807	0.681	.001	49	view →
LGG	OS	Median	All	0.741	0.869	<.001	36	view →
BRCA	OS	Quartile	III,IV	0.295	0.692	.003	30	view →
THYM	DFS	Median	All	0.792	0.938	.004	26	view →
LIHC	OS	Median	All	0.700	0.858	<.001	25	view →
GBM	DFS	Median	All	0.209	0.305	.018	23	view →
CESC	OS	Median	All	0.921	0.824	.002	22	view →
LAML	DFS	Median	All	0.430	0.700	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PIR–KIRP (DFS)

Open the KIRP breakdown →