PIR

Across TCGA cell cohorts, PIR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,531 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PIR-associated GO terms across cancer lineages are Glycoside metabolic process, Ketone metabolic process, and Polyketide metabolic process. Each is linked with PIR in more than 11 cancer types. Because this analysis shows association rather than direction, both PIR-to-partner and partner-to-PIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycoside metabolic process grouped by PIR-low versus PIR-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIR→partner) and Y-score (partner→PIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Glycoside metabolic process →	+0.335	+2.877	<.001	<.001	3	12
OESOPHAGUS	Ketone metabolic process →	+0.139	+1.706	.002	.001	3	11
LUNG_NSCLC_LUSC	Polyketide metabolic process →	+0.471	+2.291	.001	.003	3	11
LUNG_NSCLC_LUSC	Doxorubicin metabolic process →	+0.471	+2.291	.001	.003	3	11
URINARY_TRACT	Monocyte differentiation →	+0.224	+1.655	<.001	.001	3	10
LUNG_NSCLC_LUSC	Progesterone metabolic process →	+0.483	+1.884	.002	.009	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,531 associations by consensus.

Glycoside metabolic process by PIR expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →