PIPSL

Across TCGA patient cohorts, PIPSL mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIPSL-associated genes across cancer lineages are C-Raf, Caspase-7-cleavedD198, and 14-3-3_epsilon. Each is linked with PIPSL in more than 1 cancer types. Because this analysis shows association rather than direction, both PIPSL-to-partner and partner-to-PIPSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PIPSL-low versus PIPSL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIPSL→partner) and Y-score (partner→PIPSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.127	+2.841	.045	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.492	+1.720	.018	.025	3	2
COAD	14-3-3_epsilon →	+0.115	+2.501	.039	.010	3	1
UCEC	EGFR_pY1068 →	-0.254	-1.662	.004	.011	3	1
UCEC	eIF4E →	+0.159	+2.906	.032	.001	3	1
UCEC	A-Raf_pS299 →	-0.089	-2.115	.035	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

C-Raf by PIPSL expression — COAD

Explore this box plot interactively →