PIPOX

Across TCGA patient cohorts, PIPOX protein abundance is significantly associated with the RNA expression of many other genes, with 5,196 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PIPOX-associated genes across cancer lineages are THG1L, CCT8, and ANKRD27. Each is linked with PIPOX in more than 2 cancer types. Because this analysis shows association rather than direction, both PIPOX-to-partner and partner-to-PIPOX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIPOX versus THG1L in CCRCC, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIPOX→partner) and Y-score (partner→PIPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	THG1L →	-0.277	-0.428	.001	<.001	3	3
BRCA	CCT8 →	-0.651	-0.825	.002	.003	3	3
BRCA	ANKRD27 →	-0.642	-0.814	.005	<.001	3	2
GBM	EDRF1 →	-0.429	-0.928	<.001	<.001	3	2
LUAD	NPRL2 →	-0.417	-0.670	<.001	<.001	3	2
GBM	PPP1R8 →	-0.181	-0.854	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,196 associations by consensus.

PIPOX vs THG1L — CCRCC

Explore this scatter interactively →