PIP5K1A

Across TCGA pan-cancer cohorts, PIP5K1A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIP5K1A data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIP5K1A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIP5K1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where PIP5K1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.155	0.720	<.001	41	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.920	.042	6	view →
CCRCC	OS	Median	IV	0.167	0.784	.038	6	view →
LUAD	OS	Quartile	All	0.848	0.450	.031	4	view →
UCEC	OS	Median	All	0.960	0.867	.044	2	view →
LSCC	DFS	Median	III,IV	0.859	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIP5K1A–PDAC (OS)

Open the PDAC breakdown →