PIP5K1A

Across TCGA pan-cancer cohorts, PIP5K1A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PIP5K1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIP5K1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIP5K1A is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where PIP5K1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIP5K1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.909	<.001	12	view →
LIHC	All	III,IV	+1.056	<.001	9	view →
LUAD	Male	II,III,IV	+0.629	<.001	9	view →
KICH	Female	All	−1.466	<.001	8	view →
BRCA	All	II,III,IV	+0.729	<.001	6	view →
STAD	All	All	+0.598	<.001	6	view →
KIRC	All	II,III,IV	−0.325	<.001	6	view →
CHOL	Male	All	+2.498	<.001	5	view →
COAD	Male	II,III,IV	+0.454	<.001	5	view →
THCA	All	All	−0.297	.014	3	view →
UCEC	All	All	+0.412	.018	2	view →
LUSC	All	All	+0.410	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PIP5K1A–HNSC

Open the HNSC breakdown →