PIP5K1A

Across TCGA cell cohorts, PIP5K1A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIP5K1A-associated GO terms across cancer lineages are Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, Chromosome condensation, and Regulation of RNA export from nucleus. Each is linked with PIP5K1A in more than 13 cancer types. Because this analysis shows association rather than direction, both PIP5K1A-to-partner and partner-to-PIP5K1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery grouped by PIP5K1A-low versus PIP5K1A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP5K1A→partner) and Y-score (partner→PIP5K1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.129	+0.807	.003	.005	3	14
SOFT_TISSUE	Chromosome condensation →	+0.124	+0.588	<.001	<.001	3	14
BONE	Regulation of RNA export from nucleus →	+0.100	+0.594	.005	.007	3	14
STOMACH	Positive regulation of mRNA processing →	+0.154	+1.142	<.001	<.001	3	14
LARGE_INTESTINE	Transcription initiation at RNA polymerase II promoter →	+0.062	+0.946	<.001	<.001	3	13
OVARY	mRNA 3'-end processing →	+0.108	+1.056	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,374 associations by consensus.

Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery by PIP5K1A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →