PIP5K1A

Across TCGA cell cohorts, PIP5K1A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PIP5K1A-associated genes across cancer lineages are ASB17, GZMK, and USP17L13. Each is linked with PIP5K1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP5K1A-to-partner and partner-to-PIP5K1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by PIP5K1A-low versus PIP5K1A-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP5K1A→partner) and Y-score (partner→PIP5K1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
BLOOD_Leukemia	GZMK →	+0.528	+4.037	<.001	.004	3	1
BLOOD_Leukemia	USP17L13 →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	USP17L17 →	+0.004	+4.984	<.001	.002	3	1
LUNG_NSCLC_LUAD	ZC2HC1B →	+0.033	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5M8 →	+0.025	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ASB17 by PIP5K1A expression — OVARY

Explore this box plot interactively →