PIP4K2C

Across TCGA pan-cancer cohorts, PIP4K2C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIP4K2C data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIP4K2C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIP4K2C expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where PIP4K2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.387	0.769	.002	17	view →
LSCC	DFS	Median	All	0.999	0.881	.004	13	view →
HNSC	DFS	Quartile	All	0.928	0.659	.016	6	view →
CCRCC	OS	Tertile	All	0.927	0.792	.030	4	view →
GBM	DFS	Median	All	0.842	0.652	.007	3	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIP4K2C–LUAD (DFS)

Open the LUAD breakdown →