PIP4K2C

Across TCGA pan-cancer cohorts, PIP4K2C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIP4K2C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PIP4K2C RNA is repressed in tumor relative to normal tissue. In most cancer types PIP4K2C is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where PIP4K2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIP4K2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.393	<.001	12	view →
HNSC	All	III,IV	+1.154	<.001	12	view →
BLCA	Female	All	+0.997	<.001	10	view →
LIHC	Female	II,III,IV	+1.320	<.001	9	view →
LUAD	All	III,IV	+0.886	<.001	9	view →
BRCA	All	III,IV	+1.168	<.001	8	view →
LUSC	Male	II,III,IV	+0.714	<.001	8	view →
STAD	Male	II,III,IV	+0.729	.008	5	view →
KICH	All	II,III,IV	−0.394	.008	4	view →
CHOL	All	All	+2.350	<.001	3	view →
PAAD	All	All	+1.147	.008	2	view →
KIRP	Male	All	−0.529	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIP4K2C–KIRC

Open the KIRC breakdown →