PIP4K2C

Across TCGA patient cohorts, PIP4K2C protein abundance is significantly associated with the RNA expression of many other genes, with 9,009 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIP4K2C-associated genes across cancer lineages are ORMDL2, ARF3, and RAB5B. Each is linked with PIP4K2C in more than 5 cancer types. Because this analysis shows association rather than direction, both PIP4K2C-to-partner and partner-to-PIP4K2C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIP4K2C versus ORMDL2 in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4K2C→partner) and Y-score (partner→PIP4K2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ORMDL2 →	+0.435	+0.333	<.001	<.001	3	6
OV	ARF3 →	+0.404	+0.276	.008	.003	3	6
BRCA	RAB5B →	+0.658	+0.442	<.001	<.001	2	6
BRCA	TMBIM6 →	+0.467	+0.247	<.001	.004	3	5
OV	PYM1 →	+0.541	+0.446	<.001	<.001	2	6
LUAD	DCTN2 →	+0.489	+0.321	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,009 associations by consensus.

PIP4K2C vs ORMDL2 — BRCA

Explore this scatter interactively →