PIP4K2C

Across TCGA patient cohorts, PIP4K2C mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP4K2C-associated genes across cancer lineages are Gab2, PKC-delta_pS664, and eEF2. Each is linked with PIP4K2C in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP4K2C-to-partner and partner-to-PIP4K2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PIP4K2C-low versus PIP4K2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4K2C→partner) and Y-score (partner→PIP4K2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.386	+2.321	.031	.035	3	2
UCEC	PKC-delta_pS664 →	-0.139	-3.160	.020	.019	3	2
UCEC	eEF2 →	+0.381	+2.321	.034	.035	3	1
UCEC	ERK2 →	+0.271	+2.999	.005	.035	3	1
UCEC	FoxM1 →	+0.422	+3.459	.001	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.257	-3.169	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Gab2 by PIP4K2C expression — UCEC

Explore this box plot interactively →