PIP4K2B

Across TCGA pan-cancer cohorts, PIP4K2B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIP4K2B data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PIP4K2B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIP4K2B expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where PIP4K2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	0.458	1.000	.007	24	view →
LSCC	DFS	Quartile	II,III,IV	0.564	0.991	.004	18	view →
HNSC	OS	Median	II,III,IV	0.816	0.879	.042	2	view →
GBM	DFS	Median	All	0.811	0.679	.007	2	view →
CCRCC	DFS	Median	All	0.886	0.576	.030	1	view →
LUAD	OS	Tertile	All	0.673	0.924	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIP4K2B–UCEC (OS)

Open the UCEC breakdown →